与无肌病性皮肌炎及CD8 T淋巴细胞相关的致死性快速进展性间质性肺炎
Fatal rapidly progressive interstitial pneumonitis associated with amyopathic dermatomyositis and CD8 T lymphocytes.
作者信息
Yokoyama Toshinobu, Sakamoto Teruo, Shida Norihiko, Kinoshita Masaharu, Kunou Yoshifumi, Karukaya Ritsuko, Takamatsu Manabu, Aizawa Hisamichi
机构信息
First Department of Internal Medicine, Kurume University School of Medicine, Japan.
出版信息
J Intensive Care Med. 2005 May-Jun;20(3):160-3. doi: 10.1177/0885066605275391.
A patient with amyopathic dermatomyositis associated with fatal rapidly progressive interstitial pneumonitis resistant to therapy is described. Pathologic examination of a transbronchial lung biopsy specimen showed diffuse alveolar damage and nonspecific interstitial pneumonia-organizing pneumonia-like findings. Bronchoalveolar lavage fluid contained many CD8+ lymphocytes, considered to be cytotoxic T cells. Analysis of bronchoalveolar lavage fluid in this case may provide prognostically and pathogenetically important information.
本文描述了一名患有无肌病性皮肌炎的患者，其伴有对治疗耐药的致命性快速进展性间质性肺炎。经支气管肺活检标本的病理检查显示弥漫性肺泡损伤以及非特异性间质性肺炎-机化性肺炎样表现。支气管肺泡灌洗液中含有许多CD8+淋巴细胞，被认为是细胞毒性T细胞。对该病例支气管肺泡灌洗液的分析可能会提供在预后和发病机制方面重要的信息。
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