McKie S, Del-Ben C, Elliott R, Williams S, del Vai N, Anderson I, Deakin J F W
Neuroscience and Psychiatry Unit, The University of Manchester, Manchester, UK.
Psychopharmacology (Berl). 2005 Aug;180(4):680-6. doi: 10.1007/s00213-005-2270-y. Epub 2005 May 12.
Serotonin (5-hydroxytryptamine, 5-HT) is implicated in the aetiology and treatment of a variety of psychiatric disorders. A limitation of research has been the necessity to use indirect measures of 5-HT function.
We describe a method of analysing pharmacoMRI data using SPM and apply it to the direct i.v. infusion of selective 5-HT reuptake inhibitor, citalopram, in 12 healthy volunteers. Scanning took place on a 1.5-T Philips MRI scanner.
Areas implicated in depression and its treatment were observed to have increasing signal with respect to time. These areas included the caudate, the amygdala, the hippocampus, the striatum and the thalamus.
Direct pMRI using i.v. citalopram opens new ways of investigating 5-HT mechanism in depression and its treatment.
血清素（5-羟色胺，5-HT）与多种精神疾病的病因及治疗有关。研究的一个局限在于需要使用血清素功能的间接测量方法。
我们描述了一种使用统计参数映射（SPM）分析药物磁共振成像（pharmacoMRI）数据的方法，并将其应用于对12名健康志愿者静脉直接输注选择性5-羟色胺再摄取抑制剂西酞普兰的研究。扫描在一台1.5-T飞利浦磁共振成像扫描仪上进行。
观察到与抑郁症及其治疗相关的区域信号随时间增加。这些区域包括尾状核、杏仁核、海马体、纹状体和丘脑。
静脉注射西酞普兰的直接药物磁共振成像为研究抑郁症及其治疗中的血清素机制开辟了新途径。
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