Pocernich Chava B, Sultana Rukhsana, Mohmmad-Abdul Hafiz, Nath Avindra, Butterfield D Allan
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA.
Brain Res Brain Res Rev. 2005 Dec 1;50(1):14-26. doi: 10.1016/j.brainresrev.2005.04.002.
Oxidative stress is thought to play a role in the onset of dementia. HIV-dementia has recently been demonstrated to be associated with oxidative stress as indexed by increased protein and lipid peroxidation in the brain and cerebrospinal fluid compared to HIV non-demented patients. The HIV protein Tat induces neurotoxicity, and, more recently, Tat was found to induce oxidative stress directly and indirectly. The role of Tat in HIV-dementia and possible therapeutic strategies involving endogenous and exogenous antioxidants are discussed.
氧化应激被认为在痴呆症的发病过程中起作用。最近有研究表明，与未患痴呆症的HIV患者相比，HIV痴呆症与氧化应激有关，其指标是大脑和脑脊液中蛋白质和脂质过氧化增加。HIV蛋白Tat具有神经毒性，最近还发现Tat可直接或间接诱导氧化应激。本文讨论了Tat在HIV痴呆症中的作用以及涉及内源性和外源性抗氧化剂的可能治疗策略。
