从蛙脑鉴定出26RFa：一种在哺乳动物中具有促食欲活性的新型下丘脑神经肽。
Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals.
作者信息
Chartrel Nicolas, Bruzzone Federica, Dujardin Cynthia, Leprince Jerome, Tollemer Helene, Anouar Youssef, Vallarino Mauro, Costentin Jean, Vaudry Hubert
机构信息
European Institute for Peptide Research (IFRMP 23), Laboratory of Cellular and Molecular Neuroendocrinology, INSERM U413, University of Rouen, Mont-Saint-Aignan, France.
出版信息
Ann N Y Acad Sci. 2005 Apr;1040:80-3. doi: 10.1196/annals.1327.009.
In the present study, we report the identification, in the frog brain, of a novel neuropeptide, termed 26RFa, that belongs to the RFamide peptide family. The cDNAs encoding the precursors for 26RFa have been characterized in human and rats. In rats, prepro-26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior. Intracerebroventricular injection of 26RFa in mice induced a dose-dependent increase in food consumption. Taken together, these data indicate that 26RFa is a novel neuropeptide that may have important biological functions in vertebrates.
在本研究中，我们报告了在蛙脑中鉴定出一种新型神经肽，称为26RFa，它属于RFamide肽家族。编码26RFa前体的cDNA已在人类和大鼠中得到表征。在大鼠中，前激素原-26RFa mRNA仅在下丘脑两个参与进食行为控制的核中表达。向小鼠脑室内注射26RFa会导致食物摄入量呈剂量依赖性增加。综上所述，这些数据表明26RFa是一种新型神经肽，可能在脊椎动物中具有重要的生物学功能。
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