突尼斯斯法克斯市五日热巴尔通体心内膜炎的高患病率。

High prevalence of Bartonella quintana endocarditis in Sfax, Tunisia.

作者信息

Znazen Abir, Rolain Jean-Marc, Hammami Nader, Kammoun Samir, Hammami Adnane, Raoult Didier

机构信息

Unité des Rickettsies, CNRS UMR 6020, Université de la Méditerranée, Faculté de Médecine, Marseille, France.

出版信息

Am J Trop Med Hyg. 2005 May;72(5):503-7.

PMID:15891120

Abstract

Bartonella quintana is a fastidious microorganism associated with blood culture negative endocarditis. In this study, 40 sera with cross-reactivity between Chlamydia species from patients from Sfax, Tunisia, were serologically tested for Bartonella. Thirteen sera were positive for Bartonella with IgG titers >/=1:800. Western blot and cross-absorption confirmed the diagnosis of Bartonella quintana endocarditis in 12 cases and Bartonella henselae endocarditis in 1 case. These sera were also positive by LightCycler nested PCR amplification for the rnpb (7 of 13) and fur (11 of 13) genes. Eleven patients had a definite diagnosis of endocarditis, which represents 9.8% of all endocarditis. Because Bartonella endocarditis seems to be very common in Tunisia, we suggest that its serology be performed systematically whenever endocarditis is suspected.

摘要

五日热巴尔通体是一种与血培养阴性心内膜炎相关的苛求微生物。在本研究中，对来自突尼斯斯法克斯的患者中40份与衣原体属有交叉反应的血清进行了巴尔通体血清学检测。13份血清巴尔通体检测呈阳性，IgG滴度≥1:800。免疫印迹和交叉吸收法确诊12例五日热巴尔通体心内膜炎和1例亨氏巴尔通体心内膜炎。这些血清通过LightCycler巢式PCR扩增rnpb（13份中的7份）和fur（13份中的11份）基因也呈阳性。11例患者被明确诊断为心内膜炎，占所有心内膜炎患者的9.8%。由于巴尔通体心内膜炎在突尼斯似乎非常常见，我们建议每当怀疑有心内膜炎时都应系统地进行其血清学检测。