Iversen L H, Pedersen L, Riis A, Friis S, Laurberg S, Sørensen H T
Department of Surgery L, Aarhus University Hospital, Denmark.
Br J Surg. 2005 Jul;92(7):873-80. doi: 10.1002/bjs.4978.
Survival rates for patients with colorectal cancer have been lower in Denmark than in other European countries. The aim of this study was to examine temporal trends in relative survival from colorectal cancer between 1977 and 1999.
All patients diagnosed with colorectal cancer between 1977 and 1999 were identified using the nationwide population-based Danish Cancer Registry. Patients were linked with the Danish Central Population Registry to obtain data on survival to December 2002, and to select ten population controls per patient.
A total of 69 562 patients with colorectal cancer were identified, of whom 49.2 per cent were men. Six-month relative survival after diagnosis increased from 69.7 per cent in 1977-1982 to 77.7 per cent in 1995-1999. Five-year relative survival rates increased from 37.8 to 46.8 per cent respectively. Women had slightly higher 5-year relative survival than men throughout the study period. Rectal tumours were associated with better survival than colonic tumours until 2 years after diagnosis, after which tumour location had no impact on survival.
Relative survival of patients with colorectal cancer has improved in Denmark between 1977 and 1999, most probably reflecting better management of the disease.
丹麦结直肠癌患者的生存率低于其他欧洲国家。本研究的目的是调查1977年至1999年间结直肠癌相对生存率的时间趋势。
利用全国性的基于人群的丹麦癌症登记处，确定了1977年至1999年间所有被诊断为结直肠癌的患者。患者与丹麦中央人口登记处建立联系，以获取截至2002年12月的生存数据，并为每位患者选择10名人群对照。
共确定了69562例结直肠癌患者，其中49.2%为男性。诊断后6个月的相对生存率从1977 - 1982年的69.7%上升至1995 - 1999年的77.7%。5年相对生存率分别从37.8%升至46.8%。在整个研究期间，女性的5年相对生存率略高于男性。直到诊断后2年，直肠肿瘤的生存率高于结肠肿瘤，此后肿瘤位置对生存率没有影响。
1977年至1999年间，丹麦结直肠癌患者的相对生存率有所提高，这很可能反映了对该疾病的更好管理。
