Kendall Adam R, Mahue-Giangreco Maya, Carpenter Catherine L, Ganz Patricia A, Bernstein Leslie
Department of Preventive Medicine and Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA.
Qual Life Res. 2005 Mar;14(2):361-71. doi: 10.1007/s11136-004-1468-5.
Behavioral and lifestyle factors may influence quality of life (QOL) outcomes in breast cancer survivors.
Information on QOL (Short Form-36, SF-36), lifestyle and survivorship was collected during telephone interviews with 374 breast cancer patients, diagnosed between 1983 and 1988 at ages 40 years or younger and interviewed, on average 13.2 years following diagnosis. These women previously participated in a case-control study soon after their diagnoses, providing information on breast cancer risk factors including exercise activity. We examined the impact of changes in exercise activity (comparing pre- to post-diagnosis levels) on the SF-36 mental and physical health summary scales using regression analyses.
A positive change in exercise activity was associated with a higher score on the SF-36 physical health summary scale at follow-up (p = 0.005). Change in exercise activity was not associated with the SF-36 mental health summary scale score. Patients who increased their activity levels did not differ from those who did not in terms of medical or demographic characteristics.
This study provides one of the longest follow-up periods of breast cancer survivors to date among studies that focus on QOL and is unique in its focus on women diagnosed at a young age. Our results confirm high levels of functioning and well-being among long-term survivors and indicate that women whose exercise activity increased following diagnosis score higher on the SF-36 physical health summary scale. These findings suggest a potential role for exercise activity in maintaining well-being after a cancer diagnosis.
行为和生活方式因素可能会影响乳腺癌幸存者的生活质量（QOL）结果。
在对374名乳腺癌患者进行电话访谈时收集了有关生活质量（简短健康调查问卷-36，SF-36）、生活方式和生存情况的信息，这些患者于1983年至1988年期间被诊断出患有乳腺癌，年龄在40岁及以下，平均在诊断后13.2年接受访谈。这些女性在确诊后不久曾参与一项病例对照研究，提供了包括运动活动在内的乳腺癌风险因素信息。我们使用回归分析研究了运动活动变化（比较诊断前与诊断后的水平）对SF-36心理健康和身体健康总结量表的影响。
运动活动的积极变化与随访时SF-36身体健康总结量表得分较高相关（p = 0.005）。运动活动的变化与SF-36心理健康总结量表得分无关。运动水平增加的患者在医学或人口统计学特征方面与未增加的患者没有差异。
本研究提供了迄今为止乳腺癌幸存者最长的随访期之一，在关注生活质量的研究中独具特色，尤其关注年轻时被诊断出的女性。我们的结果证实了长期幸存者具有较高的功能水平和幸福感，并表明诊断后运动活动增加的女性在SF-36身体健康总结量表上得分更高。这些发现表明运动活动在癌症诊断后维持幸福感方面可能发挥作用。
