N(4)-苯基-2-苯甲酰基吡啶硫代半卡巴腙锡(IV)配合物的结构研究及细胞毒性活性
Structural studies and cytotoxic activity of N(4)-phenyl-2-benzoylpyridine thiosemicarbazone Sn(IV) complexes.
作者信息
Perez-Rebolledo Anayive, Ayala José Danilo, de Lima Geraldo M, Marchini Nicoletta, Bombieri Gabriella, Zani Carlos L, Souza-Fagundes Elaine M, Beraldo Heloisa
机构信息
Departamento de Química, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
出版信息
Eur J Med Chem. 2005 May;40(5):467-72. doi: 10.1016/j.ejmech.2005.01.006. Epub 2005 Feb 24.
Structural studies and an investigation of the cytotoxic activity of Sn(IV) complexes with N(4)-phenyl-2-benzoylpyridine thiosemicarbazone (H2Bz4Ph) were carried out. The crystal and molecular structures of [Sn(2Bz4Ph)Cl3].CH3CH2OH (1) and [Sn(2Bz4Ph)BuCl2].H2O (Bu = butyl group) (2) were determined. Both compounds present octahedral coordination geometry with the 2Bz4Ph anionic ligand behaving as tridentate on the metal ion. A comparative study of the structures of these compounds along with that of [Sn(2Bz4Ph)Bu2Cl] (3) determined before is presented. The cytotoxicity of H2Bz4Ph and its Sn(IV) complexes was investigated against the MCF-7, TK-10 and UACC-62 human tumor cell lines. Among the three complexes, 3 proved to be better as cytotoxic agent than the clinically used drug etoposide. H2Bz4Ph and all complexes were able to induce apoptosis in UACC-62 cells.
开展了对锡（IV）与N（4）-苯基-2-苯甲酰基吡啶硫代半卡巴腙（H2Bz4Ph）配合物的结构研究及其细胞毒性活性研究。测定了[Sn(2Bz4Ph)Cl3].CH3CH2OH（1）和[Sn(2Bz4Ph)BuCl2].H2O（Bu = 丁基）（2）的晶体结构和分子结构。两种化合物均呈现八面体配位几何构型，2Bz4Ph阴离子配体在金属离子上表现为三齿配体。本文对这些化合物的结构与之前测定的[Sn(2Bz4Ph)Bu2Cl]（3）的结构进行了对比研究。研究了H2Bz4Ph及其锡（IV）配合物对MCF-7、TK-10和UACC-62人肿瘤细胞系的细胞毒性。在这三种配合物中，3被证明作为细胞毒性剂比临床使用的药物依托泊苷更好。H2Bz4Ph和所有配合物都能够诱导UACC-62细胞凋亡。
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