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萘醌硫代半卡巴腙和半卡巴腙的镍（II）配合物：合成、结构、光谱学及生物活性

Nickel (II) complexes of naphthaquinone thiosemicarbazone and semicarbazone: synthesis, structure, spectroscopy, and biological activity.

作者信息

Afrasiabi Zahra, Sinn Ekk, Lin Weisheng, Ma Yinfa, Campana Charles, Padhye Subhash

机构信息

Department of Chemistry, University of Missouri-Rolla, Rolla, MO 65409, USA.

出版信息

J Inorg Biochem. 2005 Jul;99(7):1526-31. doi: 10.1016/j.jinorgbio.2005.04.012.

DOI:10.1016/j.jinorgbio.2005.04.012
PMID:15927263
Abstract

Ni(II) complexes of ortho-naphthaquinone thiosemicarbazone and semicarbazone were synthesized and spectroscopically characterized. The X-ray crystal structure of both the complexes describe a distorted octahedral coordination with two tridentate mono-deprotonated ligands. In vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazone analogue.

摘要

合成了邻萘醌硫代半卡巴腙和半卡巴腙的镍（II）配合物，并通过光谱对其进行了表征。两种配合物的X射线晶体结构均显示出与两个三齿单去质子化配体形成的扭曲八面体配位。对MCF-7人乳腺癌细胞的体外抗癌研究表明，半卡巴腙衍生物及其镍配合物在抑制细胞增殖方面比硫代半卡巴腙类似物更具活性。

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