Rusiecki Jennifer A, Matthews Aleyama, Sturgeon Susan, Sinha Rashmi, Pellizzari Edo, Zheng Tongzhang, Baris Dalsu
Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, EPS 8111, Bethesda, MD 20892-7240, USA.
Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1113-24. doi: 10.1158/1055-9965.EPI-04-0356.
We used data from a breast cancer pilot study carried out in Kerala, India in 1997, for which organochlorine levels were measured in three biological media, blood serum, breast adipose tissue, and gluteal adipose tissue, of 37 fasting breast cancer cases (pretreatment). Our objective was to investigate the relationships between organochlorine concentrations in different biological media. Gas-liquid chromatography determined serum, breast adipose, and gluteal adipose tissue levels of dichlorodiphenyltricholorethane, dichlorodiphenyldichloroethane, beta-benzene hexachloride, and polychlorinated biphenyl (PCB) congeners, PCB-153 and PCB-180. Correlation plots were made and Spearman correlation coefficients (r) calculated for breast adipose tissue versus serum, gluteal adipose tissue versus serum, and breast adipose versus gluteal adipose tissue. We also examined paired ratios of all summary statistics. There were strong correlations among serum, breast adipose tissue, and gluteal adipose tissue concentrations for most organochlorines analyzed, one exception being gluteal versus serum for PCB-153. The correlations for all other comparisons ranged from r = 0.65 to 0.94. Serum (ng/g) versus adipose ratios approached 1:1 for most of the organochlorine pesticide comparisons and did not vary by summary statistic. To our knowledge, this is the first study to use three different media from fasting subjects and to comprehensively investigate the relationship between organochlorines measured across the three media for both organochlorine pesticides and PCBs. These data indicate that blood serum reflects the present body burden of a range of organochlorines to the same extent as adipose tissue, and they support the view that serum may be collected in lieu of adipose tissue to obtain similar information. However, such measurements are a combination of both recent exposures and past exposures, which have metabolized slowly and may still persist. Therefore, investigators should use caution when assigning a level as lifetime body burden.
我们使用了1997年在印度喀拉拉邦开展的一项乳腺癌试点研究的数据，该研究测量了37例空腹乳腺癌病例（治疗前）血清、乳房脂肪组织和臀脂肪组织这三种生物介质中的有机氯水平。我们的目的是研究不同生物介质中有机氯浓度之间的关系。气液色谱法测定了血清、乳房脂肪组织和臀脂肪组织中滴滴涕、滴滴伊、β-六六六和多氯联苯同系物（PCB-153和PCB-180）的水平。绘制了相关性图，并计算了乳房脂肪组织与血清、臀脂肪组织与血清以及乳房脂肪与臀脂肪组织之间的斯皮尔曼相关系数（r）。我们还检查了所有汇总统计量的配对比率。在所分析的大多数有机氯中，血清、乳房脂肪组织和臀脂肪组织浓度之间存在很强的相关性，唯一的例外是PCB-153的臀脂肪组织与血清之间的相关性。所有其他比较的相关系数范围为r = 0.65至0.94。对于大多数有机氯农药比较，血清（ng/g）与脂肪组织的比率接近1:1，并且不随汇总统计量而变化。据我们所知，这是第一项使用来自空腹受试者的三种不同介质，并全面研究有机氯农药和多氯联苯在这三种介质中所测有机氯之间关系的研究。这些数据表明，血清在反映一系列有机氯当前身体负担方面与脂肪组织的程度相同，并且支持可以采集血清代替脂肪组织来获取类似信息的观点。然而，此类测量是近期暴露和过去暴露的综合结果，过去暴露的代谢缓慢且可能仍然存在。因此，研究人员在将某一水平指定为终生身体负担时应谨慎。
Zotero 插件