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基因疫苗的免疫学见解。

Immunological insights from genetic vaccines.

作者信息

Ertl Hildegund C J

机构信息

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

出版信息

Virus Res. 2005 Jul;111(1):89-92. doi: 10.1016/j.virusres.2005.03.015. Epub 2005 Apr 7.

Abstract

E1-deleted adenoviral vectors expressing the rabies virus glycoprotein rapidly induce protective titers of rabies virus neutralizing antibodies in adult and neonatal mice upon systemic or mucosal immunization. Pre-existing immunity in humans due to natural infections with common human serotypes of adenovirus such as the human serotype 5, most commonly used as a vaccine carrier can be circumvented by systemic immunization with a simian-origin adenovirus or by using the oral route of immunization. Virus neutralizing antibody titers can be enhanced by prime-boost regimens.

摘要

表达狂犬病病毒糖蛋白的E1缺失腺病毒载体,经全身或黏膜免疫后,可在成年和新生小鼠中迅速诱导出具有保护性效价的狂犬病病毒中和抗体。由于人类天然感染常见人类血清型腺病毒(如最常用于疫苗载体的人类血清型5)而产生的预先存在的免疫力,可通过用猿猴源腺病毒进行全身免疫或采用口服免疫途径来规避。通过初免-加强免疫方案可提高病毒中和抗体效价。

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