Brun Alejandro, Albina Emmanuel, Barret Tom, Chapman David A G, Czub Markus, Dixon Linda K, Keil Günther M, Klonjkowski Bernard, Le Potier Marie-Frédérique, Libeau Geneviève, Ortego Javier, Richardson Jennifer, Takamatsu Haru-H
Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, 28130 Madrid, Spain.
Vaccine. 2008 Dec 2;26(51):6508-28. doi: 10.1016/j.vaccine.2008.09.044.
The recent advances in molecular genetics, pathogenesis and immunology have provided an optimal framework for developing novel approaches in the rational design of vaccines effective against viral epizootic diseases. This paper reviews most of the viral-vector based antigen delivery systems (ADSs) recently developed for vaccine testing in veterinary species, including attenuated virus and DNA and RNA viral vectors. Besides their usefulness in vaccinology, these ADSs constitute invaluable tools to researchers for understanding the nature of protective responses in different species, opening the possibility of modulating or potentiating relevant immune mechanisms involved in protection.
分子遗传学、发病机制和免疫学的最新进展为开发新方法以合理设计有效的抗病毒性动物流行病疫苗提供了一个理想框架。本文综述了最近开发的用于兽医物种疫苗测试的大多数基于病毒载体的抗原递送系统（ADSs），包括减毒病毒以及DNA和RNA病毒载体。除了在疫苗学中的用途外，这些ADSs还为研究人员提供了宝贵工具，有助于了解不同物种中保护性反应的本质，从而有可能调节或增强参与保护的相关免疫机制。
