用于兽用疫苗开发的抗原递送系统。基于病毒载体的递送系统。
Antigen delivery systems for veterinary vaccine development. Viral-vector based delivery systems.
作者信息
Brun Alejandro, Albina Emmanuel, Barret Tom, Chapman David A G, Czub Markus, Dixon Linda K, Keil Günther M, Klonjkowski Bernard, Le Potier Marie-Frédérique, Libeau Geneviève, Ortego Javier, Richardson Jennifer, Takamatsu Haru-H
机构信息
Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, 28130 Madrid, Spain.
出版信息
Vaccine. 2008 Dec 2;26(51):6508-28. doi: 10.1016/j.vaccine.2008.09.044.
Abstract
The recent advances in molecular genetics, pathogenesis and immunology have provided an optimal framework for developing novel approaches in the rational design of vaccines effective against viral epizootic diseases. This paper reviews most of the viral-vector based antigen delivery systems (ADSs) recently developed for vaccine testing in veterinary species, including attenuated virus and DNA and RNA viral vectors. Besides their usefulness in vaccinology, these ADSs constitute invaluable tools to researchers for understanding the nature of protective responses in different species, opening the possibility of modulating or potentiating relevant immune mechanisms involved in protection.
摘要
分子遗传学、发病机制和免疫学的最新进展为开发新方法以合理设计有效的抗病毒性动物流行病疫苗提供了一个理想框架。本文综述了最近开发的用于兽医物种疫苗测试的大多数基于病毒载体的抗原递送系统（ADSs），包括减毒病毒以及DNA和RNA病毒载体。除了在疫苗学中的用途外，这些ADSs还为研究人员提供了宝贵工具，有助于了解不同物种中保护性反应的本质，从而有可能调节或增强参与保护的相关免疫机制。
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本文引用的文献
1
Complete protection of cats against feline panleukopenia virus challenge by a recombinant canine adenovirus type 2 expressing VP2 from FPV.一种表达来自猫细小病毒（FPV）的VP2的重组犬2型腺病毒对猫细小病毒攻击的完全保护作用。
Vaccine. 2008 Mar 10;26(11):1482-7. doi: 10.1016/j.vaccine.2007.11.073. Epub 2007 Dec 18.
2
The magnitude of the CD8+ T cell response produced by recombinant virus vectors is a function of both the antigen and the vector.重组病毒载体产生的CD8 + T细胞反应的强度是抗原和载体两者的函数。
Cell Immunol. 2007 Nov-Dec;250(1-2):55-67. doi: 10.1016/j.cellimm.2008.01.005. Epub 2008 Mar 3.
3
Bovine adenoviral vector-based H5N1 influenza vaccine overcomes exceptionally high levels of pre-existing immunity against human adenovirus.基于牛腺病毒载体的H5N1流感疫苗克服了针对人腺病毒预先存在的极高水平免疫力。
Mol Ther. 2008 May;16(5):965-71. doi: 10.1038/mt.2008.12. Epub 2008 Feb 26.
4
Global trends in emerging infectious diseases.新发传染病的全球趋势。
Nature. 2008 Feb 21;451(7181):990-3. doi: 10.1038/nature06536.
5
A recombinant pseudorabies virus expressing rabies virus glycoprotein: safety and immunogenicity in dogs.一种表达狂犬病病毒糖蛋白的重组伪狂犬病病毒：犬类的安全性和免疫原性
Vaccine. 2008 Mar 4;26(10):1314-21. doi: 10.1016/j.vaccine.2007.12.050. Epub 2008 Jan 22.
6
Oral adenoviral-based vaccines: historical perspective and future opportunity.基于腺病毒的口服疫苗：历史回顾与未来机遇
Expert Rev Vaccines. 2008 Feb;7(1):25-31. doi: 10.1586/14760584.7.1.25.
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J Virol. 2008 Feb;82(3):1368-77. doi: 10.1128/JVI.02007-07. Epub 2007 Nov 7.
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