哺乳动物中介体复合物及其在转录调控中的作用。

The mammalian Mediator complex and its role in transcriptional regulation.

作者信息

Conaway Ronald C, Sato Shigeo, Tomomori-Sato Chieri, Yao Tingting, Conaway Joan W

机构信息

Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

出版信息

Trends Biochem Sci. 2005 May;30(5):250-5. doi: 10.1016/j.tibs.2005.03.002.

DOI:10.1016/j.tibs.2005.03.002

PMID:15896743

Abstract

Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.

摘要

中介体是RNA聚合酶II通用转录机制的重要组成部分，在真核生物mRNA合成的激活和抑制中起着关键作用。酿酒酵母中介体是首个被定义的中介体，它是一种高分子量复合物，由20多个不同的亚基组成，在转录过程中发挥多种作用。最近的研究确定了哺乳动物中介体的亚基组成和相关活性，并揭示了从酵母到人类中介体结构和功能的显著进化保守性。