纤维蛋白胶在肾部分切除术中应用的可能性与局限性：实验研究
Possibilities and limitations of fibrin glue usage in nephron-sparing surgery: experimental study.
作者信息
Stojkovic Ivica, Savic Vojin, Djokic Milan, Balint Bela, Ljubenovic Slobodan, Ignjatovic Ivan
机构信息
Clinic of Urology, Clinical Center Nis, Nis, Serbia and Montenegro.
出版信息
Urol Int. 2005;74(4):355-60. doi: 10.1159/000084438.
INTRODUCTION
The possibilities and limitations of fibrin glue (FG) usage in nephron-sparing surgery were studied.
MATERIALS AND METHODS
A prospective experimental study was carried out in 50 pigs: 30 with polar resection, and 20 with mediorenal wedge resection of the kidney. Hemostatic sutures, FG, and FG with a muscle 'cup' in animals with polar resection of the kidney were compared. FG and sutures in animals with the wedge resection of the kidney were studied as well. Bleeding, hot ischemia time, complication rate, and additional scarring were also analyzed.
RESULTS
Suture hemostasis is safe but with significant adverse effects in both polar and wedge resection of kidney. FG was not efficient as a sole hemostatic agent for polar resection. It was as efficient as hemostatic suture for wedge resection of the kidney. FG with a muscle 'cup' on a pole of the kidney achieved good results in animals with polar resection of the kidney. Histological analysis confirmed better results with FG because of both the less intense and smaller area of additional scarring.
CONCLUSION
FG is a reliable and efficient hemostatic agent for nephron-sparing surgery whenever both sided gluing is possible.
引言
研究了纤维蛋白胶（FG）在保留肾单位手术中的应用可能性和局限性。
材料与方法
对50头猪进行了一项前瞻性实验研究：30头进行肾极切除术，20头进行肾中部楔形切除术。比较了肾极切除术动物中使用的止血缝线、FG以及带有肌肉“杯”的FG。还研究了肾楔形切除术动物中的FG和缝线。分析了出血情况、热缺血时间、并发症发生率和额外瘢痕形成情况。
结果
缝线止血是安全的，但在肾极切除术和楔形切除术中均有明显的不良反应。FG作为肾极切除术的单一止血剂效果不佳。它在肾楔形切除术中与止血缝线效果相当。在肾极切除术的动物中，在肾极处带有肌肉“杯”的FG取得了良好效果。组织学分析证实，由于额外瘢痕形成的强度较低且面积较小，FG取得了更好的效果。
结论
只要有可能进行双侧粘贴，FG就是保留肾单位手术中一种可靠且有效的止血剂。
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