Tauxe-Wuersch A, De Alencastro L F, Grandjean D, Tarradellas J
Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory of Environmental Chemistry and Ecotoxicology, CH-1015 Lausanne, Switzerland.
Water Res. 2005 May;39(9):1761-72. doi: 10.1016/j.watres.2005.03.003. Epub 2005 Apr 15.
The occurrence and fate of five acidic drugs (Mefenamic acid, Ibuprofen, Ketoprofen, Diclofenac and Clofibric acid) were analysed in three sewage treatment plants (STP) over 4-7 consecutive days. The results point out that the five substances were persistent in wastewater effluents after municipal wastewater treatment. At the most, half of Mefenamic acid was eliminated. Ibuprofen was well removed (80%) by one sewage treatment plant. The removal of Ibuprofen is dependent on the residence time of wastewater in the STPs. A long raining period induce an important decrease of removal of Ibuprofen and Ketoprofen. Removal rates showed a great variability according to sewage treatment plants and types of treatments (e.g. biological, physico-chemical). The concentrations of Ibuprofen, Mefenamic acid and Diclofenac were relatively high in the effluents (150-2000 ng/l), showing a potential contamination of surface water. An environmental risk assessment is presented. Mefenamic acid seems to present a risk for the aquatic environment, with a ratio PEC/PNEC higher than one.
连续4至7天，对三家污水处理厂（STP）中五种酸性药物（甲芬那酸、布洛芬、酮洛芬、双氯芬酸和氯贝酸）的存在情况及归宿进行了分析。结果表明，城市污水处理后，这五种物质在废水排放中具有持久性。甲芬那酸最多只有一半被去除。一家污水处理厂对布洛芬的去除效果良好（80%）。布洛芬的去除取决于废水在污水处理厂中的停留时间。长时间降雨会导致布洛芬和酮洛芬的去除率大幅下降。去除率因污水处理厂和处理类型（如生物处理、物理化学处理）的不同而有很大差异。废水中布洛芬、甲芬那酸和双氯芬酸的浓度相对较高（150 - 2000纳克/升），表明地表水存在潜在污染。本文进行了环境风险评估。甲芬那酸对水生环境似乎存在风险，其预测环境浓度（PEC）与预测无效应浓度（PNEC）之比高于1。
