Sahloff Eric G
Department of Pharmacy Practice, College of Pharmacy, University of Toledo, OH 43606, USA.
Pharmacotherapy. 2005 May;25(5):741-7. doi: 10.1592/phco.25.5.741.63589.
Infection with the human immunodeficiency virus (HIV) continues to affect millions of people worldwide. Preventive measures have done little to slow the transmission of the virus. Discovery of an effective vaccine to prevent HIV could have a tremendous impact on this global pandemic. However, the complex interactions between HIV and the host immune system have limited the progress in vaccine development. Traditional vaccination strategies have shown little promise. Currently, subunit vaccines, DNA vaccines, recombinant vector vaccines, and prime-boost strategies are being evaluated in clinical trials. Although many breakthroughs have been made in HIV vaccine research, only three candidate HIV vaccines have been studied in phase III clinical trials. The current strategies being investigated in the development of preventive HIV vaccines are reviewed.
人类免疫缺陷病毒（HIV）感染继续影响着全球数百万人。预防措施在减缓病毒传播方面收效甚微。发现一种有效的预防HIV疫苗可能会对这一全球大流行产生巨大影响。然而，HIV与宿主免疫系统之间复杂的相互作用限制了疫苗研发的进展。传统的疫苗接种策略成效甚微。目前，亚单位疫苗、DNA疫苗、重组载体疫苗和初免 - 加强策略正在临床试验中进行评估。尽管HIV疫苗研究已取得许多突破，但只有三种候选HIV疫苗进入了III期临床试验。本文综述了目前在预防性HIV疫苗研发中所研究的策略。
