Munakata Satoru, Watanabe Omi, Ohashi Kazutomo, Morino Hideo
Department of Pathology, Kansai Rosai Hospital, Amagasaki, Japan.
Am J Clin Pathol. 2005 Jun;123(6):879-85. doi: 10.1309/0773-N4Q3-GFP3-4J5V.
Apoptosis-related factors are known to influence survival with many malignant tumors. We performed immunohistochemical analysis of Fas ligand (FasL) and bcl-2 in invasive cervical cancer to determine the association with prognosis. In 125 patients with cervical cancer, 93 cases (74.4%) were positive for FasL, and 94 cases (75.2%) were positive for bcl-2. When 101 cases, clinical stages I through IV, were analyzed by univariate analysis, negative bcl-2 (P = .035) and combined positive FasL and negative bcl-2 (PFNB; P = .0025) were associated with significantly decreased disease-free survival. Positive FasL (P = .042), negative bcl-2 (P = .0004), and PFNB (P < .0001) were associated with a significantly worse prognosis in overall survival. In clinical stages II through IV, positive FasL (P = .04), negative bcl-2 (P = .002), and PFNB (P < .0001) had significant associations with shorter disease-free survival and positive FasL (P = .049), negative bcl-2 (P < .0001), and PFNB (P < .0001) with worse overall survival.
已知凋亡相关因子会影响多种恶性肿瘤的生存率。我们对浸润性宫颈癌中的Fas配体（FasL）和bcl-2进行了免疫组织化学分析，以确定其与预后的关系。在125例宫颈癌患者中，93例（74.4%）FasL呈阳性，94例（75.2%）bcl-2呈阳性。对临床分期为I至IV期的101例患者进行单因素分析时，bcl-2阴性（P = 0.035）以及FasL阳性与bcl-2阴性联合（PFNB；P = 0.0025）与无病生存率显著降低相关。FasL阳性（P = 0.042）、bcl-2阴性（P = 0.0004）和PFNB（P < 0.0001）与总生存率显著较差相关。在临床分期为II至IV期的患者中，FasL阳性（P = 0.04）、bcl-2阴性（P = 0.002）和PFNB（P < 0.0001）与无病生存期较短显著相关，FasL阳性（P = 0.049）、bcl-2阴性（P < 0.0001）和PFNB（P < 0.0001）与总生存率较差相关。
