通过甲基化的3H-吡咯并[2,3-d]嘧啶-2(7H)-酮核苷类似物识别DNA三链螺旋中的CG倒位。
Recognition of CG inversions in DNA triple helices by methylated 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues.
作者信息
Ranasinghe Rohan T, Rusling David A, Powers Vicki E C, Fox Keith R, Brown Tom
机构信息
School of Chemistry, University of Southampton, Highfield, Southampton, UK SO17 1BJ.
出版信息
Chem Commun (Camb). 2005 May 28(20):2555-7. doi: 10.1039/b502325d. Epub 2005 Apr 14.
DOI:10.1039/b502325d
PMID:15900324
Abstract
Substituted 3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one nucleoside analogues have been synthesised from 5-alkynyl-uridine derivatives, incorporated into triplex forming oligonucleotides (TFOs) and found to selectively bind CG inversions with enhanced affinity compared to T.
摘要
已从5-炔基尿苷衍生物合成了取代的3H-吡咯并[2,3-d]嘧啶-2(7H)-酮核苷类似物，将其掺入三链形成寡核苷酸（TFO）中，发现与T相比，它们能以更高的亲和力选择性结合CG倒位。
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