Department of Chemistry, Binghamton University, The State University of New York, Binghamton, New York 13902, USA.
Chem Commun (Camb). 2011 Oct 21;47(39):11125-7. doi: 10.1039/c1cc14706d. Epub 2011 Sep 12.
Peptide nucleic acids containing 2-pyrimidinone (P) and 3-oxo-2,3-dihydropyridazine (E) heterocycles recognized C-G and U-A inversions in a polypurine tract of double helical RNA with high affinity and sequence selectivity at pH 6.25. E-modified PNA bound strongly to bacterial A-site RNA, while no binding was observed to the human A-site RNA.
含有 2-嘧啶酮 (P) 和 3-氧代-2,3-二氢哒嗪 (E) 杂环的肽核酸在 pH 6.25 时以高亲和力和序列选择性识别双链 RNA 中富含嘌呤的序列中的 C-G 和 U-A 反转。E 修饰的 PNA 与细菌 A 位 RNA 结合紧密，而与人 A 位 RNA 则观察不到结合。
