环氧孪二醇A是一种由真菌产生的具有C2对称性的新型独特血管生成抑制剂。
Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.
作者信息
Kakeya Hideaki, Onose Rie, Koshino Hiroyuki, Osada Hiroyuki
机构信息
Antibiotics Laboratory, Discovery Research Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
出版信息
Chem Commun (Camb). 2005 May 28(20):2575-7. doi: 10.1039/b501392e. Epub 2005 Mar 15.
DOI:10.1039/b501392e
PMID:15900331
Abstract
We isolated a novel unique pentaketide dimer designated as epoxytwinol A from the fermentation broth of a fungus. The structure of epoxytwinol A was determined to have a new carbon skeleton with C(2) symmetry by elucidation of spectroscopic evidence. Epoxytwinol A inhibited endothelial cell migration stimulated by vascular endothelial growth factor (ED(100)= 2.6 microM).
摘要
我们从一种真菌的发酵液中分离出一种新型独特的五酮二聚体，命名为环氧孪二醇A。通过光谱证据的阐释，确定环氧孪二醇A具有一个具有C(2)对称性的新碳骨架。环氧孪二醇A抑制血管内皮生长因子刺激的内皮细胞迁移（ED(100)= 2.6 microM）。
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