Jia M C, Zhou L Y, Ren S, Dong L, Xiao B
National Research Institute for Family Planning, Beijing, People's Republic of China.
Adv Contracept. 1992 Mar;8(1):33-40. doi: 10.1007/BF01849346.
Daily serum sex hormone binding globulin (SHBG) levels were measured during normal ovulatory menstrual cycles in ten women between the ages of 23 and 34 by the method of precipitation with ammonium sulfate. The results showed that the mean SHBG levels in a cycle were quite different among individuals, but that the SHBG levels were constant during a certain menstrual cycle. Neither SHBG peaks on day LH-0 (52.64 +/- 19.89 nmol/L) (x +/- SD) nor the mean SHBG levels between the follicular phase (57.10 +/- 17.64 nmol/L) and luteal phase (64.75 +/- 23.42 nmol/L) show any significant differences. The correlations between the mean SHBG levels and the mean concentrations of progesterone (P), estradiol (E2) and androstenedione during the menstrual cycles were insignificant, whereas the mean SHBG levels during the follicular and luteal phase and on LH-0 day were significantly correlated with the mean concentrations of testosterone (t = 0.474; p less than 0.05). In ten women between the ages of 25 and 34, serum SHBG, E2, P, and levonorgestrel (LNG) levels were measured once on day 20-21 of the pretreatment cycle and 3 times/week during the 1st, and 2 times/week during the 6th treatment cycle after insertion of a levonorgestrel-releasing IUD (LNG-IUD). The mean value of SHBG in the pretreatment blood samples (62.09 +/- 23.09 nmol/L) was higher than that after insertion of the LNG-IUD (41.82 +/- 20.50 nmol/L), though the difference was not significant (p greater than 0.05). The correlation between LNG and SHBG was highly significant (r = 0.89, p less than 0.01). The significance of this correlation and the degree of suppression of ovarian function are discussed.
采用硫酸铵沉淀法，对10名年龄在23至34岁之间的女性正常排卵月经周期中的每日血清性激素结合球蛋白（SHBG）水平进行了测量。结果显示，一个周期内SHBG的平均水平在个体间差异较大，但在特定月经周期内SHBG水平保持恒定。在促黄体生成素（LH）-0日（52.64±19.89 nmol/L）（x±标准差）的SHBG峰值，以及卵泡期（57.10±17.64 nmol/L）和黄体期（64.75±23.42 nmol/L）之间的SHBG平均水平均无显著差异。月经周期中SHBG平均水平与孕酮（P）、雌二醇（E2）和雄烯二酮平均浓度之间的相关性不显著，而卵泡期、黄体期以及LH-0日的SHBG平均水平与睾酮平均浓度显著相关（t = 0.474；p＜0.05）。对10名年龄在25至34岁之间的女性，在放置左炔诺孕酮宫内节育器（LNG-IUD）前周期的第20 - 21天测量一次血清SHBG、E2、P和左炔诺孕酮（LNG）水平，在放置后第1个治疗周期每周测量3次，第6个治疗周期每周测量2次。放置LNG-IUD前血样中SHBG的平均值（62.09±23.09 nmol/L）高于放置后（41.82±20.50 nmol/L），尽管差异不显著（p＞0.05）。LNG与SHBG之间的相关性高度显著（r = 0.89，p＜0.01）。讨论了这种相关性的意义以及卵巢功能的抑制程度。
