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A novel anti-anti-activator mechanism regulates expression of the Pseudomonas aeruginosa type III secretion system.一种新型的抗抗激活因子机制调控铜绿假单胞菌III型分泌系统的表达。
Mol Microbiol. 2004 Jul;53(1):297-308. doi: 10.1111/j.1365-2958.2004.04128.x.
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Regulatory circuits and communication in Gram-negative bacteria.革兰氏阴性菌中的调控回路与通讯
Nat Rev Microbiol. 2004 Jul;2(7):581-92. doi: 10.1038/nrmicro924.
3
Expression of Pseudomonas aeruginosa exoS is controlled by quorum sensing and RpoS.铜绿假单胞菌外毒素S的表达受群体感应和RpoS调控。
Microbiology (Reading). 2004 Apr;150(Pt 4):843-851. doi: 10.1099/mic.0.26703-0.
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Modulation of enteropathogenic Escherichia coli virulence by quorum sensing.群体感应调控肠道致病性大肠杆菌的毒力
Infect Immun. 2004 Apr;72(4):2329-37. doi: 10.1128/IAI.72.4.2329-2337.2004.
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Bacterial communication: tiny teamwork.细菌通讯:微小的团队协作。
Nature. 2003 Jul 10;424(6945):134. doi: 10.1038/424134a.
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Bacteria-host communication: the language of hormones.细菌与宿主的交流:激素的语言。
Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8951-6. doi: 10.1073/pnas.1537100100. Epub 2003 Jul 7.
7
Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment.铜绿假单胞菌群体感应调控子的微阵列分析:生长阶段和环境的影响
J Bacteriol. 2003 Apr;185(7):2080-95. doi: 10.1128/JB.185.7.2080-2095.2003.
8
Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis.铜绿假单胞菌群体感应控制基因的鉴定、时间及信号特异性:转录组分析
J Bacteriol. 2003 Apr;185(7):2066-79. doi: 10.1128/JB.185.7.2066-2079.2003.
9
Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway.通过一条新的依赖腺苷酸环化酶的信号通路对细菌毒力基因进行协同调控。
Dev Cell. 2003 Feb;4(2):253-63. doi: 10.1016/s1534-5807(03)00019-4.
10
ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon.ExsD是铜绿假单胞菌III型分泌调节子的负调节因子。
Mol Microbiol. 2002 Nov;46(4):1123-33. doi: 10.1046/j.1365-2958.2002.03228.x.

群体感应负向调控铜绿假单胞菌PAO1中III型分泌调节子的表达。

Quorum sensing negatively controls type III secretion regulon expression in Pseudomonas aeruginosa PAO1.

作者信息

Bleves Sophie, Soscia Chantal, Nogueira-Orlandi Patricia, Lazdunski Andrée, Filloux Alain

机构信息

Laboratoire d'Ingénierie des Systèmes Macromoléculaires, CNRS-IBSM-UPR9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France.

出版信息

J Bacteriol. 2005 Jun;187(11):3898-902. doi: 10.1128/JB.187.11.3898-3902.2005.

DOI:10.1128/JB.187.11.3898-3902.2005
PMID:15901720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1112058/
Abstract

A systematic analysis of the type III secretion (T3S) genes of Pseudomonas aeruginosa strain PAO1 revealed that they are under quorum-sensing control. This observation was supported by the down-regulation of the T3S regulon in the presence of RhlR-C4HSL and the corresponding advanced secretion of ExoS in a rhlI mutant.

摘要

对铜绿假单胞菌PAO1菌株的III型分泌(T3S)基因进行的系统分析表明,这些基因受群体感应控制。在存在RhlR-C4HSL的情况下T3S调节子的下调以及rhlI突变体中ExoS相应的提前分泌支持了这一观察结果。