Solbakk Anne-Kristin, Reinvang Ivar, Svebak Sven, Nielsen Christopher S, Sundet Kjetil
Department of Psychology, University of Oslo, Blindern, Norway.
J Clin Exp Neuropsychol. 2005 Feb;27(2):205-23. doi: 10.1080/13803390490515739.
We examined whether closed head injury patients show altered patterns of selective attention to stimulus categories that naturally evoke differential responses in healthy people. Self-reported rating and electrophysiological (event-related potentials [ERPs], heart rate [HR]) responses to affective pictures were studied in patients with mild head injury (n = 20; CT/MRI negative), in patients with predominantly frontal brain lesions (n = 12; CT/MRI confirmed), and in healthy controls (n = 20). Affective valence similarly modulated HR and ERP responses in all groups, but group differences occurred that were independent of picture valence. The attenuation of P3-slow wave amplitudes in the mild head injury group indicates a reduction in the engagement of attentional resources to the task. In contrast, the general enhancement of ERP amplitudes at occipital sites in the group with primarily frontal brain injury may reflect disinhibition of input at sensory receptive areas, possibly due to a deficit in top-down modulation performed by anterior control systems.
我们研究了闭合性颅脑损伤患者对刺激类别的选择性注意模式是否发生改变，这些刺激类别在健康人身上会自然引发不同的反应。我们对轻度颅脑损伤患者（n = 20；CT/MRI检查为阴性）、主要为额叶脑损伤患者（n = 12；CT/MRI检查确诊）和健康对照组（n = 20）进行了自我报告评分以及对情感图片的电生理反应（事件相关电位[ERP]、心率[HR]）研究。情感效价在所有组中对HR和ERP反应的调节方式相似，但出现了与图片效价无关的组间差异。轻度颅脑损伤组中P3慢波振幅的衰减表明对任务的注意力资源投入减少。相比之下，主要为额叶脑损伤组枕叶部位ERP振幅的普遍增强可能反映了感觉感受区域输入的去抑制，这可能是由于前控制系统自上而下调节功能的缺陷所致。
