Brumer Yisroel, Shakhnovich Eugene I
Harvard University, Cambridge, Massachusetts 02138, USA.
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Mar;71(3 Pt 1):031903. doi: 10.1103/PhysRevE.71.031903. Epub 2005 Mar 8.
In this article we study the full semiconservative treatment of a model for the coevolution of a virus and an adaptive immune system. Regions of viability are calculated for both conservatively and semiconservatively replicating viruses interacting with a realistic semiconservatively replicating immune system. The conservative virus is found to have a selective advantage in the form of an ability to survive in regions with a wider range of mutation rates than its semiconservative counterpart, as well as an increased replication rate where both species can survive. This may help explain the existence of a rich range of viruses with conservatively replicating genomes, a trait that is found nowhere else in nature.
在本文中，我们研究了一种病毒与适应性免疫系统协同进化模型的完全半保守处理。计算了与现实的半保守复制免疫系统相互作用的保守和半保守复制病毒的生存区域。发现保守病毒具有选择性优势，表现为在比其半保守对应物更广泛的突变率范围内生存的能力，以及在两种物种都能生存的区域中增加的复制率。这可能有助于解释存在大量具有保守复制基因组的病毒，这种特性在自然界其他地方都不存在。
