Chamaraux F, Fache S, Bruckert F, Fourcade B
Si3M-DRFMC CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 09, France.
Phys Rev Lett. 2005 Apr 22;94(15):158102. doi: 10.1103/PhysRevLett.94.158102. Epub 2005 Apr 20.
Cell spreading is a fundamental event where the contact area with a solid substrate increases because of actin polymerization. We propose in this Letter a physical model to study the growth of the contact area with time. This analysis is compared with experimental data using the ameoba Dictyostelium discoideum. Our model couples the stress, which builds up at the margin of the contact area when the cell spreads, to the biochemical processes of actin polymerization. This leads to a scaling analysis of experimental data with a characteristic time whose order of magnitude compares well with our experimental results.
细胞铺展是一个基本过程，在此过程中，由于肌动蛋白聚合，细胞与固体基质的接触面积会增大。在本信函中，我们提出了一个物理模型来研究接触面积随时间的增长情况。我们将此分析结果与使用盘基网柄菌进行的实验数据进行了比较。我们的模型将细胞铺展时在接触区域边缘积累的应力与肌动蛋白聚合的生化过程联系起来。这导致对实验数据进行标度分析，得到一个特征时间，其量级与我们的实验结果吻合得很好。
