Morimoto T, Yoshimatsu M, Nagao H, Matsuda H
Department of Pediatrics, Ehime University School of Medicine, Japan.
Brain Dev. 1992 Jan;14(1):53-7. doi: 10.1016/s0387-7604(12)80280-4.
Three types of rat hyperthermic seizures were observed. The first comprised generalized clonic convulsions preceded by intermittent myoclonus. Ictal EEG showed diffuse intermittent spikes and sequential rapid spike-wave bursts (type 1 seizures). In the other types of seizures, the paroxysmal discharges originated in the occipital region without (type 2a seizures) or with (type 2b seizures) secondary generalization. Type 2a seizures involved no convulsive movement whereas type 2b seizures involved clonic convulsions. The threshold temperatures for type 1, 2a and 2b seizures were 44.1 +/- 0.60, 40.9 +/- 1.47 and 42.1 +/- 0.75 degrees C, respectively. Of these seizures, the type 2 seizures (2a and 2b) did not severely affect the general condition of rats and thus may be an appropriate model for the investigation of febrile seizures.
观察到三种类型的大鼠高热惊厥。第一种包括先有间歇性肌阵挛的全身性阵挛性抽搐。发作期脑电图显示弥漫性间歇性棘波和连续快速棘慢波爆发（1型发作）。在其他类型的惊厥中，阵发性放电起源于枕叶区域，无继发泛化（2a型发作）或有继发泛化（2b型发作）。2a型发作不涉及惊厥运动，而2b型发作涉及阵挛性抽搐。1型、2a型和2b型发作的阈值温度分别为44.1±0.60、40.9±1.47和42.1±0.75摄氏度。在这些惊厥中，2型惊厥（2a型和2b型）对大鼠的一般状况影响不严重，因此可能是研究热性惊厥的合适模型。
