Tamim Muhammed, Bové Thierry, Van Belleghem Yves, François Katrien, Taeymans Yves, Van Nooten Guido J
Heart Centre, Cardiac Surgery Department, University Hospital Ghent, Ghent, Belgium.
Asian Cardiovasc Thorac Ann. 2005 Jun;13(2):112-8. doi: 10.1177/021849230501300204.
The aim of this retrospective study was to evaluate the time-related regression of left ventricular hypertrophy after stentless vs. stented aortic valve replacement. From January 1992 to December 2002, 145 patients had a Toronto stentless porcine valve and 106 had a stented Carpentier-Edwards aortic valve replacement. Over a 10-year follow-up, survival was superior in the Toronto group vs. the Carpentier-Edwards group (84% vs. 74% at 4 years; 78% vs. 68% at 6 years; p < 0.001). A significant and constant reduction of peak and mean transvalvular gradients after valve replacement resulted in substantial regression of left ventricular mass index in both groups, which did not reach statistical significance. However, this phenomenon stopped at 3 years, and left ventricular mass index increased slowly after 5 years. Stentless and stented bioprostheses both showed good early and late clinical and hemodynamic outcomes, with the advantage of better midterm survival for stentless xenografts.
这项回顾性研究的目的是评估无支架与有支架主动脉瓣置换术后左心室肥厚的时间相关消退情况。从1992年1月至2002年12月，145例患者接受了多伦多无支架猪瓣膜置换，106例患者接受了有支架的Carpentier-Edwards主动脉瓣置换。在10年的随访中，多伦多组的生存率高于Carpentier-Edwards组（4年时分别为84%和74%；6年时分别为78%和68%；p<0.001）。瓣膜置换术后跨瓣峰值和平均梯度显著且持续降低，导致两组左心室质量指数大幅消退，但未达到统计学显著性。然而，这种现象在3年后停止，5年后左心室质量指数缓慢增加。无支架和有支架生物假体均显示出良好的早期和晚期临床及血流动力学结果，无支架异种移植物在中期生存方面具有更好的优势。
