Monsoro-Burq Anne-Hélène
Institut Curie, Section Recherche, UMR 146, Centre Universitaire, Orsay, France.
Int J Dev Biol. 2005;49(2-3):301-8. doi: 10.1387/ijdb.041953am.
The vertebra develops from the ventral part of the somite, the sclerotome. Sclerotome progenitors are subject to multiple signaling molecules secreted by the adjacent tissues that control their fate. The aim of this article is to discuss the mechanisms of sclerotome induction, chondrogenesis and morphogenesis. By integrating the results from classical studies and recent molecular advances, this will illustrate how the powerful combination of experimental embryology and genetic approaches has recently illuminated the multiple steps of vertebra formation.
椎骨由体节的腹侧部分即生骨节发育而来。生骨节祖细胞受到相邻组织分泌的多种信号分子的调控，这些信号分子控制着它们的命运。本文旨在探讨生骨节诱导、软骨形成和形态发生的机制。通过整合经典研究结果和近期的分子进展，将阐明实验胚胎学和遗传学方法的有力结合如何在最近揭示了椎骨形成的多个步骤。
