Rodrigues A C L, Schellini S A, Gregório E A, Spadella C T, Padovani C R
Department of Ophthalmology, School of Medicine of Botucatu, State University, São Paulo State, Brazil.
J Submicrosc Cytol Pathol. 2004 Jul-Oct;36(3-4):327-31.
This study aims to evaluate the diabetic influence on the choroidal vessels morphology. Twenty Wistar rats were divided into a control (CG) and a diabetic group (DG). The animals had the diabetes induced by an intra-venous injection of Alloxan (42 mg/kg). Transmission electron microscopy analysis focusing the choroidal vessels was done one (T2) and twelve (T3) months after the diabetes induction. The CG rats in T3 showed vesicles and dense bodies in the endothelial and pericytic cells; the same structures were observed in the DG at T2. The DG rats in T3 had even more and intense changes than the T2DG rats. The morphological evaluation indicates that the choroidal vessels are affected in diabetes and the disease accelerates degenerative processes in the rat choroidal vasculature.
本研究旨在评估糖尿病对脉络膜血管形态的影响。将20只Wistar大鼠分为对照组（CG）和糖尿病组（DG）。通过静脉注射四氧嘧啶（42 mg/kg）诱导动物患糖尿病。在糖尿病诱导后1个月（T2）和12个月（T3）进行聚焦于脉络膜血管的透射电子显微镜分析。T3时CG组大鼠的内皮细胞和周细胞中可见小泡和致密体；在T2时DG组也观察到相同结构。T3时DG组大鼠的变化比T2时DG组大鼠更多且更明显。形态学评估表明，糖尿病会影响脉络膜血管，且该疾病会加速大鼠脉络膜血管系统的退行性进程。
