Labat Francoise, Pradillon Olivier, Garry Louis, Peuchmaur Michel, Fantin Bruno, Denamur Erick
INSERM E0339, Faculté de Médecine Xavier Bichat, Université Paris 7, 16 rue Henri Huchard, 75018 Paris, France.
FEMS Immunol Med Microbiol. 2005 Jun 1;44(3):317-21. doi: 10.1016/j.femsim.2005.01.003.
It has been suggested that mutator phenotype could be associated with an increase in virulence, but to date experimental evidences are lacking. Epidemiological studies have revealed that urinary tract infection isolates encompass the highest proportion of mutator strains within the Escherichia coli species. Using the uropathogenic strain CFT073 and its mutS- mutator mutant, we show that the mutator strain is selected in vitro in urine and in the late stages of infection in a mouse model having urinary tract infection. Thus, we report that, under specific conditions, i.e., urinary tract infection, the mutator phenotype may confer an advantage in pathogenesis.
有人提出突变体表型可能与毒力增加有关，但迄今为止仍缺乏实验证据。流行病学研究表明，在大肠杆菌属中，尿路感染分离株中突变菌株的比例最高。利用尿路致病性菌株CFT073及其mutS突变体，我们发现突变菌株在体外尿液中以及在患有尿路感染的小鼠模型感染后期被选择出来。因此，我们报告，在特定条件下，即尿路感染时，突变体表型可能在发病机制中具有优势。
