吸烟与骨关节炎：尼古丁对人软骨细胞糖胺聚糖和胶原蛋白合成的不同影响。
Smoking and osteoarthritis: differential effect of nicotine on human chondrocyte glycosaminoglycan and collagen synthesis.
作者信息
Gullahorn L, Lippiello L, Karpman R
机构信息
Maricopa Medical Center Orthopaedic Residency Program, Phoenix, AZ 85006, USA.
出版信息
Osteoarthritis Cartilage. 2005 Oct;13(10):942-3. doi: 10.1016/j.joca.2005.03.001.
PMID:15908236
Abstract
Anecdotal suggestions and retrospective studies indicate an inverse relationship between the incidence of osteoarthritis and individuals who smoke. As a possible explanation, our studies confirm that nicotine upregulates glycosaminoglycan and collagen synthetic activity of articular chondrocytes at physiological levels seen in individuals who smoke.
摘要
轶事性建议和回顾性研究表明骨关节炎发病率与吸烟个体之间存在负相关关系。作为一种可能的解释，我们的研究证实，尼古丁在吸烟者生理水平上上调关节软骨细胞的糖胺聚糖和胶原蛋白合成活性。
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