• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

吸烟与骨关节炎：尼古丁对人软骨细胞糖胺聚糖和胶原蛋白合成的不同影响。

Smoking and osteoarthritis: differential effect of nicotine on human chondrocyte glycosaminoglycan and collagen synthesis.

作者信息

Gullahorn L, Lippiello L, Karpman R

机构信息

Maricopa Medical Center Orthopaedic Residency Program, Phoenix, AZ 85006, USA.

出版信息

Osteoarthritis Cartilage. 2005 Oct;13(10):942-3. doi: 10.1016/j.joca.2005.03.001.

DOI:10.1016/j.joca.2005.03.001
PMID:15908236
Abstract

Anecdotal suggestions and retrospective studies indicate an inverse relationship between the incidence of osteoarthritis and individuals who smoke. As a possible explanation, our studies confirm that nicotine upregulates glycosaminoglycan and collagen synthetic activity of articular chondrocytes at physiological levels seen in individuals who smoke.

摘要

轶事性建议和回顾性研究表明骨关节炎发病率与吸烟个体之间存在负相关关系。作为一种可能的解释，我们的研究证实，尼古丁在吸烟者生理水平上上调关节软骨细胞的糖胺聚糖和胶原蛋白合成活性。

相似文献

1
Smoking and osteoarthritis: differential effect of nicotine on human chondrocyte glycosaminoglycan and collagen synthesis.吸烟与骨关节炎：尼古丁对人软骨细胞糖胺聚糖和胶原蛋白合成的不同影响。
Osteoarthritis Cartilage. 2005 Oct;13(10):942-3. doi: 10.1016/j.joca.2005.03.001.
2
Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study.外源性鞘磷脂酶可增加原代关节软骨细胞胶原蛋白和硫酸化糖胺聚糖的生成：一项体外研究。
Arthritis Res Ther. 2006;8(4):R89. doi: 10.1186/ar1961.
3
The effects of hyaluronic acid on articular chondrocytes.透明质酸对关节软骨细胞的影响。
J Bone Joint Surg Br. 2005 Aug;87(8):1143-9. doi: 10.1302/0301-620X.87B8.15083.
4
The effect of TGF-beta1 and beta-estradiol on glycosaminoglycan and type II collagen distribution in articular chondrocyte cultures.转化生长因子β1和β-雌二醇对关节软骨细胞培养物中糖胺聚糖和II型胶原蛋白分布的影响。
Cell Biol Int. 2008 Jul;32(7):841-7. doi: 10.1016/j.cellbi.2008.03.016. Epub 2008 Apr 8.
5
Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis.波形蛋白细胞骨架的解体破坏了关节软骨软骨细胞的稳态。
Matrix Biol. 2006 Sep;25(7):398-408. doi: 10.1016/j.matbio.2006.06.002. Epub 2006 Jun 18.
6
Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats.甲状旁腺激素1-34抑制人关节软骨细胞的终末分化及大鼠骨关节炎的进展。
Arthritis Rheum. 2009 Oct;60(10):3049-60. doi: 10.1002/art.24843.
7
Nicotine promotes proliferation and collagen synthesis of chondrocytes isolated from normal human and osteoarthritis patients.尼古丁促进正常人及骨关节炎患者关节软骨细胞的增殖和胶原合成。
Mol Cell Biochem. 2012 Jan;359(1-2):263-9. doi: 10.1007/s11010-011-1020-1. Epub 2011 Aug 19.
8
Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes.用SOX9进行逆转录病毒转导可增强传代骨关节炎人关节软骨细胞中软骨细胞表型的重新表达。
Osteoarthritis Cartilage. 2005 Jan;13(1):80-9. doi: 10.1016/j.joca.2004.10.011.
9
Polysulfated glycosaminoglycan accelerates net synthesis of collagen and glycosaminoglycans by arthritic equine cartilage tissues and chondrocytes.
Am J Vet Res. 1990 May;51(5):779-85.
10
Transforming growth factor beta stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes.转化生长因子β刺激培养的兔关节软骨细胞中胶原蛋白和糖胺聚糖的生物合成。
FEBS Lett. 1988 Jul 4;234(1):172-6. doi: 10.1016/0014-5793(88)81327-9.

引用本文的文献

1
The administration of exogenous HSP47 as a collagen-specific therapeutic approach.将外源性热休克蛋白47作为一种针对胶原蛋白的治疗方法进行应用。
JCI Insight. 2025 Feb 6;10(6):e181570. doi: 10.1172/jci.insight.181570.
2
Intra-articular steroids for the treatment of coxarthrosis; a retrospective cohort study comparing three contrast techniques.关节内类固醇治疗髋关节骨关节炎; 三种对比技术的回顾性队列研究。
Arch Orthop Trauma Surg. 2024 Jul;144(7):2935-2943. doi: 10.1007/s00402-024-05371-w. Epub 2024 May 29.
3
The Impact of Nicotine Use on Osteoarthritis.
尼古丁使用对骨关节炎的影响。
Curr Rheumatol Rev. 2025;21(1):1-3. doi: 10.2174/0115733971270925240318080227.
4
Assessment of the relationship between smoking and meniscal injury.吸烟与半月板损伤之间关系的评估。
Radiol Bras. 2023 Nov-Dec;56(6):336-342. doi: 10.1590/0100-3984.2023.0081.
5
A machine learning-based approach to decipher multi-etiology of knee osteoarthritis onset and deterioration.一种基于机器学习的方法来解读膝骨关节炎发病和恶化的多种病因。
Osteoarthr Cartil Open. 2021 Jan 6;3(1):100135. doi: 10.1016/j.ocarto.2020.100135. eCollection 2021 Mar.
6
Impact of smoking on the incidence and post-operative complications of total knee arthroplasty: A systematic review and meta-analysis of cohort studies.吸烟对全膝关节置换术后发病率和并发症的影响：队列研究的系统评价和荟萃分析。
Bosn J Basic Med Sci. 2022 Jun 1;22(3):353-365. doi: 10.17305/bjbms.2021.6538.
7
Prevalence of knee osteoarthritis, its determinants, and impact on the quality of life in elderly persons in rural Ballabgarh, Haryana.哈里亚纳邦巴拉布加尔农村地区老年人膝关节骨关节炎的患病率、决定因素及其对生活质量的影响。
J Family Med Prim Care. 2021 Jan;10(1):354-360. doi: 10.4103/jfmpc.jfmpc_1477_20. Epub 2021 Jan 30.
8
Correlation between radiographic knee osteoarthritis and lifetime cigarette smoking amount in a Korean population: A cross-sectional study.韩国人群中膝关节影像学骨关节炎与终生吸烟量的相关性：一项横断面研究。
Medicine (Baltimore). 2020 Jun 26;99(26):e20839. doi: 10.1097/MD.0000000000020839.
9
Primary Human Chondrocytes Affected by Cigarette Smoke-Therapeutic Challenges.原发性人软骨细胞受香烟烟雾影响——治疗挑战。
Int J Mol Sci. 2020 Mar 10;21(5):1901. doi: 10.3390/ijms21051901.
10
The association between smoking and knee osteoarthritis in a cohort of Danish patients undergoing knee arthroscopy.吸烟与膝关节镜检查的丹麦患者队列中膝骨关节炎的相关性。
BMC Musculoskelet Disord. 2019 Apr 1;20(1):141. doi: 10.1186/s12891-019-2518-z.