溶组织内阿米巴分泌产物可降解结肠粘蛋白寡糖。
Entamoeba histolytica-secreted products degrade colonic mucin oligosaccharides.
作者信息
Moncada Darcy, Keller Kathy, Chadee Kris
机构信息
Institute of Parasitology, McGill University, 21,111 Lakeshore Road, Ste. Anne de Bellevue, Quebec, Canada H9X 3V9.
出版信息
Infect Immun. 2005 Jun;73(6):3790-3. doi: 10.1128/IAI.73.6.3790-3793.2005.
Abstract
Degradation of the mucus layer by Entamoeba histolytica is a prerequisite for invasion of the colonic mucosa. In this study, we demonstrate that amoeba-secreted products degrade (3)H-labeled and native colonic mucin oligosaccharides independently of proteolytic activity. We conclude that E. histolytica degrades mucin oligosaccharides, which may facilitate parasite invasion of the colon.
摘要
溶组织内阿米巴对黏液层的降解是其侵袭结肠黏膜的前提条件。在本研究中，我们证明阿米巴分泌的产物可独立于蛋白水解活性降解³H标记的和天然的结肠黏蛋白寡糖。我们得出结论，溶组织内阿米巴可降解黏蛋白寡糖，这可能有助于寄生虫对结肠的侵袭。
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