Shah Khalid
Center for Molecular Imaging, Massachusetts Gneral Hospital, Boston, MA, USA.
Cancer Biol Ther. 2005 May;4(5):518-23. doi: 10.4161/cbt.4.5.1706. Epub 2005 May 5.
For ensuring success of gene and cell based therapies it is of prime importance to develop technology for non-invasive monitoring of the location and duration of gene expression, distribution and targeting of therapeutically engineered cells and vector particles in vivo. A number of advances have been achieved in high resolution, in vivo imaging methods, such as bioluminescence imaging, Magnetic resonance imaging (MRI), positron emission tomography (PET) and various fluorescence imaging techniques, including fluorescence mediated tomography (FMT) and near infrared fluorescence (NIRF) reflectance imaging. In this review we will discuss different imaging modalities that have found applications in gene and cell therapies of cancer.
为确保基于基因和细胞的治疗取得成功，开发用于非侵入性监测基因表达的位置和持续时间、治疗性工程细胞和载体颗粒在体内的分布及靶向的技术至关重要。在高分辨率体内成像方法方面已取得多项进展，如生物发光成像、磁共振成像（MRI）、正电子发射断层扫描（PET）以及各种荧光成像技术，包括荧光介导断层扫描（FMT）和近红外荧光（NIRF）反射成像。在本综述中，我们将讨论已在癌症基因和细胞治疗中得到应用的不同成像方式。
