在筛查葡萄糖评估期间的母体低血糖是否能识别出有围产期不良结局风险的妊娠？

Does maternal hypoglycemia during screening glucose assessment identify a pregnancy at-risk for adverse perinatal outcome?

作者信息

Feinberg Jeffrey H, Magann Everett F, Morrison John C, Holman John R, Polizzotto Michael J

机构信息

Department of Family Practice, Naval Hospital, Camp Pendleton, Camp Pendleton, CA, USA.

出版信息

J Perinatol. 2005 Aug;25(8):509-13. doi: 10.1038/sj.jp.7211336.

DOI:10.1038/sj.jp.7211336

PMID:15908987

Abstract

OBJECTIVE

To determine the perinatal outcome in pregnancies with maternal hypoglycemia following a second trimester oral glucose challenge test (GCT).

STUDY DESIGN

Retrospective case-control study of pregnancies undergoing a second trimester 1-hour oral glucose challenge test (GCT). Hypoglycemic pregnancies (<88 mg/dl) were matched with pregnancies with 1-hour glucoses of >88 mg/dl. Antepartum, intrapartum, and neonatal outcomes were assessed.

RESULTS

Over 29 months, 334 hypoglycemic singleton pregnancies were matched with 334 controls. A greater number of special/neonatal intensive care unit (SCN/NICU) admissions occurred in the hypoglycemic group (48/334 (14.4%) vs 29/334 (8.7%) in the control group) (p=0.02). The SCN/NICU admission rate remained after controlling for maternal hypertension, smoking, and preterm birth (p=0.037). The development of pregnancy-induced hypertension in women with hypoglycemia 24/334 (7.2%) compared with euglycemic women 13/334 (3.9%, p<0.06) was not significant.

CONCLUSION

Admission to SCN/NICU is increased in pregnant women with hypoglycemia following a GCT.

摘要

目的

确定孕中期口服葡萄糖耐量试验（GCT）后出现母体低血糖的妊娠的围产期结局。

研究设计

对接受孕中期1小时口服葡萄糖耐量试验（GCT）的妊娠进行回顾性病例对照研究。低血糖妊娠（<88mg/dl）与1小时血糖>88mg/dl的妊娠进行匹配。评估产前、产时和新生儿结局。

结果

在29个月的时间里，334例低血糖单胎妊娠与334例对照进行了匹配。低血糖组入住特殊/新生儿重症监护病房（SCN/NICU）的人数更多（48/334（14.4%），对照组为29/334（8.7%））（p=0.02）。在控制了母体高血压、吸烟和早产因素后，SCN/NICU的入住率仍然较高（p=0.037）。低血糖女性发生妊娠期高血压的比例为24/334（7.2%），而血糖正常的女性为13/334（3.9%，p<0.06），差异无统计学意义。