Golaz J, Bouras C, Hof P R
Division de Psychopathologie Morphologique, Mount Sinai School of Medicine, New York, NY 10029.
J Geriatr Psychiatry Neurol. 1992 Apr-Jun;5(2):85-92. doi: 10.1177/002383099200500205.
Alzheimer's disease (AD) is characterized neuropathologically by high densities of neurofibrillary tangles (NFT) and neuritic plaques (NP) in the cerebral cortex, in particular in neocortical association areas and in the hippocampal formation. We report here the case of an AD patient who developed signs of motor dysfunction early in the clinical evolution. A quantitative neuropathologic analysis revealed much higher densities of NFT and NP in the primary motor cortex than is usually observed in AD. This case, together with other reports, points to the existence of neurologically defined subgroups of AD with unusual clinical deficits that are correlated with the regional and laminar distribution of NP and NFT, and further supports the hypothesis that the symptomatology presented by AD patients results from the loss of specific neuronal populations leading to a syndrome of global cortical disconnection.
阿尔茨海默病（AD）的神经病理学特征是大脑皮层，特别是新皮层联合区和海马结构中存在高密度的神经原纤维缠结（NFT）和神经炎性斑块（NP）。我们在此报告一例AD患者，该患者在临床病程早期出现运动功能障碍体征。定量神经病理学分析显示，初级运动皮层中NFT和NP的密度比AD通常所见要高得多。该病例以及其他报告表明，存在神经学定义的AD亚组，这些亚组具有异常的临床缺陷，与NP和NFT的区域及层状分布相关，并进一步支持了以下假说：AD患者出现的症状是由于特定神经元群体的丧失导致整体皮层失联综合征。
