Bouras C, Hof P R, Morrison J H
Département de Psychiatrie, IUPG Bel-Air, Université de Genève, Switzerland.
Neurosci Lett. 1993 Apr 30;153(2):131-5. doi: 10.1016/0304-3940(93)90305-5.
Detailed analyses of the neuropathologic changes in the cerebral cortex of elderly individuals and Alzheimer's disease patients have demonstrated that certain components of the neocortical and hippocampal circuits are likely to be selectively vulnerable. In order to investigate the distribution of lesions associated with aging as well as with the earliest symptoms of Alzheimer's disease, we performed a quantitative neuropathological evaluation of sixty-one non-demented patients from a geriatric hospital. All of the cases had neurofibrillary tangles in layer II of the entorhinal cortex, and many cases had an involvement of the CA1 field of the hippocampus and the inferior temporal cortex. In all of the cases, amyloid deposition was not correlated with age or with the number of neurofibrillary tangles. In addition, eight cases showed much higher neurofibrillary tangle counts than the remainder of the cases. It is proposed that these cases may represent the neuropathological correlate of the earliest stage of Alzheimer's disease that could antedate the appearance of clinical signs of cognitive decline and memory impairment.
对老年人和阿尔茨海默病患者大脑皮质神经病理变化的详细分析表明，新皮质和海马回路的某些成分可能特别容易受损。为了研究与衰老以及阿尔茨海默病最早症状相关的病变分布，我们对一家老年医院的61名非痴呆患者进行了定量神经病理学评估。所有病例在内嗅皮质第II层均有神经原纤维缠结，许多病例累及海马CA1区和颞下皮质。在所有病例中，淀粉样蛋白沉积与年龄或神经原纤维缠结数量均无相关性。此外，有8例的神经原纤维缠结计数远高于其余病例。有人提出，这些病例可能代表阿尔茨海默病最早阶段的神经病理学关联，可能早于认知衰退和记忆障碍临床症状的出现。
