利奈唑胺是否通过抑制线粒体蛋白质合成导致乳酸性酸中毒？
Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?
作者信息
Palenzuela Lluis, Hahn Noah M, Nelson Robert P, Arno Janet N, Schobert Carol, Bethel Robert, Ostrowski Lisa A, Sharma Manjuli R, Datta Partha P, Agrawal Rajendra K, Schwartz Jennifer E, Hirano Michio
机构信息
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, USA.
出版信息
Clin Infect Dis. 2005 Jun 15;40(12):e113-6. doi: 10.1086/430441. Epub 2005 May 3.
Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.
利奈唑胺是一种恶唑烷酮类抗生素，通过与23S核糖体RNA（rRNA）结合来抑制细菌蛋白质合成。我们研究了3例在接受利奈唑胺治疗时发生乳酸性酸中毒的患者。这种毒性可能是由利奈唑胺与线粒体16S rRNA结合所致。基因多态性可能在2例患者的毒性反应中起了作用。
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