利奈唑胺与乳酸性酸中毒：儿童长期使用利奈唑胺时监测乳酸的作用。
Linezolid and lactic acidosis: a role for lactate monitoring with long-term linezolid use in children.
机构信息
Department of Pediatric Critical Care Medicine, Division of Infectious Disease, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.
出版信息
Pediatr Infect Dis J. 2011 Sep;30(9):804-6. doi: 10.1097/INF.0b013e3182186035.
Abstract
Linezolid administration has been associated with lactic acidosis in adults; however, the same phenomenon has not been reported in children. Mitochondrial protein synthesis inhibition is a demonstrated mechanism for toxicity, which therefore may manifest as lactic acidosis. Three cases of linezolid-associated lactic acidosis in children are reported to reinforce the need for pediatric caregivers to be vigilant of this potential side effect.
摘要
利奈唑胺在成人中与乳酸性酸中毒相关；然而，在儿童中尚未有相同的现象报道。线粒体蛋白合成抑制是毒性的已知机制，因此可能表现为乳酸性酸中毒。报告了三例儿童利奈唑胺相关乳酸性酸中毒病例，以加强儿科护理人员对这种潜在副作用的警惕。
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