Shikuma Cecilia M, Valcour Victor G, Ratto-Kim Silvia, Williams Andrew E, Souza Scott, Gerschenson Mariana, Day Larry, Kim Jerome H, Shiramizu Bruce
Hawaii AIDS Clinical Research Program, John A. Burns School of Medicine, University of Hawaii-Manoa, Honolulu, Hawaii 96816, USA.
Clin Infect Dis. 2005 Jun 15;40(12):1846-8. doi: 10.1086/430376. Epub 2005 May 3.
Human immunodeficiency virus (HIV) infection in peripheral blood mononuclear cells (PBMCs) might be influencing the development of wasting in the era of potent antiretroviral therapy. In a retrospective study of 57 subjects, HIV proviral DNA levels in PBMCs were higher in subjects whose body weight decreased by >5% one year after initiation of highly active antiretroviral therapy, compared with subjects whose body weight was stable or increased (median HIV proviral DNA load, 8.9 vs. 0.9 copies/10(6) PBMCs; P = .006).
在高效抗逆转录病毒治疗时代，外周血单个核细胞（PBMC）中的人类免疫缺陷病毒（HIV）感染可能会影响消瘦的发展。在一项对57名受试者的回顾性研究中，与体重稳定或增加的受试者相比，在开始高效抗逆转录病毒治疗一年后体重下降超过5%的受试者，其PBMC中的HIV前病毒DNA水平更高（HIV前病毒DNA载量中位数分别为8.9拷贝/10⁶个PBMC和0.9拷贝/10⁶个PBMC；P = 0.006）。
