[2450兆赫微波对大鼠海马长时程增强及脑内脂褐素含量的影响]
[Effects of 2450 MHz microwave on long-term potentiation of hippocampus and lipofuscin contents in rat brain].
作者信息
Zhao Ya-li, Peng Xiao-dong, Yang Yu-hua, Ma Hong-bo, Song Jin-ping, Pu Jing-sui
机构信息
Institute of Space Medico-Engineering, Beijing, China.
出版信息
Space Med Med Eng (Beijing). 2004 Apr;17(2):111-3.
OBJECTIVE
To study the mechanism of the effects of microwave on learning and memory.
METHOD
Long-term potentiation (LTP) of hippocampus induced potential and lipofuscin content in rat brain were studied. After irradiated by a 2450 MHz microwave, rats hippocampus induced potential in vivo was recorded and lipofuscin content in the brain was measured by fluorospectrophotometry.
RESULT
Continuous microwave with 10-25 mW/cm2 intensity could inhibit the amplitude of the population spike (PS) of weak and strong stimuli induced LTP with an intensity-effect relationship. At 25 mW/cm2, lipofuscin content was significantly higher than control and 10 mW/cm2 group (P<0.05).
CONCLUSION
Continuous microwave with 10-25 mW/cm2 intensity impairs learning and memory by restraining hippocampus LTP and brain lipofuscin content.
目的
研究微波对学习和记忆影响的机制。
方法
研究大鼠脑海马诱发电位的长时程增强（LTP）及脑内脂褐素含量。用2450MHz微波辐照大鼠后，记录其海马在体诱发电位，并用荧光分光光度法测定脑内脂褐素含量。
结果
强度为10 - 25mW/cm²的连续微波可抑制强弱刺激诱导的LTP群体峰电位（PS）幅度，存在强度 - 效应关系。在25mW/cm²时，脂褐素含量显著高于对照组和10mW/cm²组（P<0.05）。
结论
强度为10 - 25mW/cm²的连续微波通过抑制海马LTP和脑内脂褐素含量损害学习和记忆。
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