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[鸡慢肌和快肌中乙酰胆碱酯酶的分子形式]

[Molecular forms of acetylcholinesterase in the slow muscle and the fast muscle of the chicken].

作者信息

Koenig J, Vigny M

出版信息

C R Seances Soc Biol Fil. 1978;172(6):1069-74.

PMID:159094
Abstract

Five molecular forms of AChE are present in the slow (ALD) and twitch (PLD) muscles of the chick. These forms have 4 S, 7 S, 11 S, 15 S and 20 S sedimentation coefficient in sucrose gradient. The heaviest forms, the 20 S and 15 S of AChE are absent in uninnervated muscles and present in innervated muscles. In innervated muscles, the 20 S and 15 S AChE are present in both nerve-free segments and end-plates zones. The 20 S and 15 S which are not specifically associated with the end-plate zones in the chick could be considered as a biochemical "marker" of neuromuscular interactions.

摘要

鸡的慢肌(ALD)和快肌(PLD)中存在五种乙酰胆碱酯酶分子形式。这些形式在蔗糖梯度中的沉降系数分别为4S、7S、11S、15S和20S。最重的形式,即乙酰胆碱酯酶的20S和15S,在未受神经支配的肌肉中不存在,而存在于受神经支配的肌肉中。在受神经支配的肌肉中,20S和15S乙酰胆碱酯酶存在于无神经节段和终板区。鸡中与终板区无特异性关联的20S和15S可被视为神经肌肉相互作用的生化“标志物”。

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