阿斯伯格综合征：家族因素及产前和围产期因素
Asperger syndrome: familial and pre- and perinatal factors.
作者信息
Gillberg Christopher, Cederlund Mats
机构信息
Department of Child and Adolescent Psychiatry, University of Göteborg, Sweden.
出版信息
J Autism Dev Disord. 2005 Apr;35(2):159-66. doi: 10.1007/s10803-004-1993-7.
OBJECTIVE
Study familial and pre- and perinatal factors in Asperger Syndrome (AS).
METHODS
One hundred boys with AS had their records reviewed. "Pathogenetic subgroups" were defined according to presence of medical syndromes/chromosomal abnormalities, indices of familiality, and pre- and perinatal risk factors predisposing to brain damage.
RESULTS
No major index of pathogenetic factors was found in 13%, a syndrome/chromosomal abnormality in 8%, pre- or perinatal risk 13%, combined pre- or perinatal risk and family history in 11%, and family history only in 55%.
COMMENT
About 50% of all boys with AS have a paternal family history of autism spectrum disorder. Pre- and perinatal risks appear to be important in about 25% of cases.
目的
研究阿斯伯格综合征（AS）的家族因素以及产前和围产期因素。
方法
对100名患有AS的男孩的记录进行回顾。根据是否存在医学综合征/染色体异常、家族性指标以及易导致脑损伤的产前和围产期危险因素来定义“致病亚组”。
结果
13%的病例未发现主要致病因素指标，8%存在综合征/染色体异常，13%有产前或围产期风险，11%既有产前或围产期风险又有家族史，仅家族史阳性的占55%。
评论
所有患有AS的男孩中约50%有自闭症谱系障碍的父系家族史。产前和围产期风险在约25%的病例中似乎很重要。
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