Petrova G V, Donchenko G V
Ukr Biokhim Zh (1999). 2004 Jan-Feb;76(1):103-7.
It has been established that alpha-tocopherol prevented rat thymocytes apoptotic death induced by low concentration (250 nM) of calcium ionophore A23187. When necrotic cell death was induced high concentration (10 microM) of calcium ionophore A23187 alpha-tocopherol was able to alter necrosis to apoptosis. It was proposed that such effect can be explained by the ability of alpha-tocopherol to prevent the mitochondrial permeability transition--a key event in apoptosis and necrosis induction.
已经证实，α-生育酚可预防低浓度（250 nM）钙离子载体A23187诱导的大鼠胸腺细胞凋亡性死亡。当高浓度（10 μM）钙离子载体A23187诱导坏死性细胞死亡时，α-生育酚能够将坏死转变为凋亡。有人提出，这种作用可以用α-生育酚预防线粒体通透性转变的能力来解释，而线粒体通透性转变是凋亡和坏死诱导中的关键事件。
