骨闪烁显像骨摄取率在血液透析患者中的应用价值
Usefulness of bone uptake ratio of bone scintigraphy in hemodialysis patients.
作者信息
Nishida Hidemi, Kaida Hayato, Ishibashi Masatoshi, Hiromatsu Yuji, Baba Kenkichi, Iida Shuji, Okuda Seiya
机构信息
Department of Nephrology and Dialysis Unit, Kurume University School of Medicine, Fukuoka, Japan.
出版信息
Ann Nucl Med. 2005 Apr;19(2):91-4. doi: 10.1007/BF03027386.
OBJECTIVE
It is important to estimate the bone metabolism in patients with renal osteodystrophy. The methods of estimation must be noninvasive, accurate, and able to measure repeatedly.
METHODS
The regions of interest on bone scintigraphy were drawn over the radius in 22 hemodialysis patients (10 males, 12 females). The bone/soft tissue ratio (B/ST ratio) was calculated for all patients. The bone soft tissue ratio of both skull (S) and radius (R) was obtained from the resultant count ratios. We investigated the correlation between intact parathyroid hormone (PTH), alkaline phosphatase (ALP) and the uptake ratios S and R.
RESULTS
Intact PTH had a significantly linear correlation with R (r = 0.745, p < 0.0001) and S (r = 0.702, p = 0.0001). ALP also had a significantly linear correlation with R (r = 0.537, p = 0.009) and S (r = 0.772, p < 0.0001).
CONCLUSION
The measurement of the bone soft tissue ratio of radius on bone scintigraphy was crucial for estimating renal osteodystrophy.
目的
评估肾性骨营养不良患者的骨代谢情况很重要。评估方法必须是非侵入性的、准确的且能够重复测量。
方法
对22例血液透析患者（10例男性，12例女性）的桡骨进行骨闪烁显像，并划定感兴趣区。计算所有患者的骨/软组织比值（B/ST比值）。从所得计数比值中获取颅骨（S）和桡骨（R）的骨软组织比值。我们研究了全段甲状旁腺激素（PTH）、碱性磷酸酶（ALP）与摄取比值S和R之间的相关性。
结果
全段PTH与R（r = 0.745，p < 0.0001）和S（r = 0.702，p = 0.0001）均呈显著线性相关。ALP与R（r = 0.537，p = 0.009）和S（r = 0.772，p < 0.0001）也呈显著线性相关。
结论
骨闪烁显像测量桡骨的骨软组织比值对评估肾性骨营养不良至关重要。
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