Maurice-Williams R S, Kitchen N D
Royal Free Hospital, Hampstead, London, UK.
Br J Neurosurg. 1992;6(2):131-7. doi: 10.3109/02688699209002915.
We have investigated the effect of age on the outcome of first time surgery for intracranial meningiomas. In a retrospective study, 144 consecutive patients were divided into three groups: young (up to 44 years of age, 38 patients), middle-aged (45-64 years, 60 patients) and elderly (65 years and over, 46 patients). Outcome was assessed at the first follow-up appointment 4-6 months after discharge. The surgical mortality was 2.7%. The incidence of significant intercurrent disease increased with age (11, 25 and 35%, respectively), as did the incidence of postoperative complications (16, 23 and 30%). Postoperative intracranial bleeding was especially age-related, occurring in 20% of the elderly group as against 0% of the younger. Although the younger patients did best (100% in Glasgow Outcome Scale Grade 5) there was no difference in outcome between the middle-age and elderly groups (88 and 83%, respectively). Of the elderly patients, 89% showed clear functional improvement after surgery, 2% were unchanged and 9% were worse or dead. The intellectual deterioration apparent in over half of the elderly patients recovered after removal of the tumour in 80%. We conclude that age has little effect on the prospects of success after removal of an intracranial meningioma.
我们研究了年龄对首次颅内脑膜瘤手术结果的影响。在一项回顾性研究中，144例连续患者被分为三组：年轻组（44岁及以下，38例患者）、中年组（45 - 64岁，60例患者）和老年组（65岁及以上，46例患者）。在出院后4 - 6个月的首次随访预约时评估结果。手术死亡率为2.7%。严重并发疾病的发生率随年龄增加（分别为11%、25%和35%），术后并发症的发生率也是如此（分别为16%、23%和30%）。术后颅内出血尤其与年龄相关，老年组发生率为20%，而年轻组为0%。尽管年轻患者效果最佳（格拉斯哥预后量表5级为100%），但中年组和老年组的结果没有差异（分别为88%和83%）。在老年患者中，89%术后功能明显改善，2%无变化，9%情况恶化或死亡。超过一半老年患者明显的智力衰退在肿瘤切除后80%得到恢复。我们得出结论，年龄对颅内脑膜瘤切除术后的成功前景影响很小。
