[多种2-甲基-(4'-氯苯甲酰基)-4-苯氧基)-2-丙酸（LF 153）类似物对大鼠肝脏线粒体呼吸活性的影响]
[Effect of various 2-methyl-(4'-chlorobenzoyl)-4-phenoxy)-2 propionic acid (LF 153) analogs on the respiratory activity of rat liver mitochondria].
作者信息
Goudonnet H, Wulfert E, de Grimal P, Truchot R
出版信息
C R Seances Soc Biol Fil. 1978;172(6):1131-6.
Seven analogs of methyl-2 [chloro-4' benzoyl)-4 phenoxy]-2 propionic acid, (LF 153) have been tested for their effects on respiration and phosphorylation of rat liver mitochondria suspensions. They differ from one another by the sort of binding between both aromatic cycle as well as by the nature and position of the halogenated substitutions and alpha methylation in the propionic chain. All the compounds which have been tested acted as inhibitors of the electron transport chain and uncouplers of phosphorylations.
已对七种甲基-2-[氯-4'-苯甲酰基)-4-苯氧基]-2-丙酸类似物（LF 153）进行了测试，以研究它们对大鼠肝脏线粒体悬浮液呼吸作用和磷酸化作用的影响。它们彼此之间的差异在于两个芳香环之间的连接方式、卤代取代基的性质和位置以及丙酸链中的α-甲基化情况。所有测试的化合物均表现为电子传递链抑制剂和磷酸化解偶联剂。
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