Reth M
Max-Planck-Institut für Immunobiologie, Freiberg, Germany.
Annu Rev Immunol. 1992;10:97-121. doi: 10.1146/annurev.iy.10.040192.000525.
Recent studies on the structure of the B cell antigen receptor demonstrate that the membrane-bound and antigen-binding immunoglobulin molecules are noncovalently associated with a heterodimer of two novel transmembrane proteins. The B cell antigen receptor is thus a multicomponent receptor complex whose structural features are similar to those of the T cell antigen receptor complex. Cross-linking of the B cell antigen receptor results in rapid tyrosine phosphorylation of substrate proteins. This suggests that the B cell receptor belongs to a subgroup of the tyrosine kinase receptor family with a noncovalently associated src-like tyrosine kinase.
近期对B细胞抗原受体结构的研究表明，膜结合型和抗原结合型免疫球蛋白分子与两种新型跨膜蛋白的异二聚体非共价结合。因此，B细胞抗原受体是一种多组分受体复合物，其结构特征与T细胞抗原受体复合物相似。B细胞抗原受体的交联导致底物蛋白迅速发生酪氨酸磷酸化。这表明B细胞受体属于酪氨酸激酶受体家族的一个亚组，带有一个非共价结合的src样酪氨酸激酶。
