Garg Renu, Pandey Kailash N
Department of Physiology, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA.
Peptides. 2005 Jun;26(6):1009-23. doi: 10.1016/j.peptides.2004.09.022. Epub 2005 Apr 13.
Natriuretic peptide receptor-A (NPRA) is the biological receptor of the peptide hormones atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). The level and activity of this receptor determines the biological effects of ANP and BNP in different tissues mainly directed towards the maintenance of salt and water homeostasis. The core transcriptional machinery of the TATA-less Npr1 gene, which encodes NPRA, consists of three SP1 binding sites and the inverted CCAAT box. This promoter region of Npr1 gene has been shown to contain several putative binding sites for the known transcription factors, but the functional significance of most of these regulatory sequences is yet to be elucidated. The present review discusses the current knowledge of the functional significance of the promoter region of Npr1 gene and its transcriptional regulation by a number of factors including different hormones, growth factors, changes in extracellular osmolarity, and certain physiological and patho-physiological conditions.
利钠肽受体-A（NPRA）是肽类激素心房利钠肽（ANP）和脑利钠肽（BNP）的生物受体。该受体的水平和活性决定了ANP和BNP在不同组织中的生物学效应，主要针对维持盐和水平衡。编码NPRA的无TATA盒的Npr1基因的核心转录机制由三个SP1结合位点和反向CCAAT盒组成。Npr1基因的该启动子区域已被证明含有几个已知转录因子的假定结合位点，但这些调控序列中大多数的功能意义尚待阐明。本综述讨论了Npr1基因启动子区域功能意义的当前知识，以及其受多种因素转录调控的情况，这些因素包括不同激素、生长因子、细胞外渗透压变化以及某些生理和病理生理状况。
