Monteleone P, Maj M, Fusco M, Kemali D, Reiter R J
Institute of Psychiatry, First Medical School, University of Naples, Italy.
Schizophr Res. 1992 Apr;7(1):77-84. doi: 10.1016/0920-9964(92)90077-i.
The 24-h profiles of plasma melatonin and cortisol were evaluated in 7 drug-free male paranoid schizophrenics and in 7 healthy subjects matched to the patients for age, sex, body weight, height and season of testing. Blood samples were obtained at 20.00, 22.00, 24.00, 01.00, 02.00, 06.00, 08.00 and 12.00 h. Light was turned off from 21.00 to 07.00 h. Compared with that of the normal controls, the circadian rhythm of plasma melatonin was absent in paranoid schizophrenics (F7.84 = 7.30, p less than 0.0001; two-way ANOVA with repeated measures) whereas the 24-h profile of plasma cortisol was preserved, although at a slightly higher level (F1.12 = 26.810, p less than 0.0002). The melatonin/cortisol ratio was significantly higher in healthy subjects than in the schizophrenic patients. A functional relationship between disturbances in the melatonin rhythm especially and schizophrenia may be proposed, although the significance of this relationship remains to be elucidated.
在7名未服用药物的男性偏执型精神分裂症患者以及7名在年龄、性别、体重、身高和测试季节方面与患者相匹配的健康受试者中，评估了血浆褪黑素和皮质醇的24小时变化情况。在20:00、22:00、24:00、01:00、02:00、06:00、08:00和12:00采集血样。从21:00至07:00熄灯。与正常对照组相比，偏执型精神分裂症患者血浆褪黑素的昼夜节律消失（F7.84 = 7.30，p < 0.0001；重复测量的双向方差分析），而血浆皮质醇的24小时变化情况得以保留，尽管水平略高（F1.12 = 26.810，p < 0.0002）。健康受试者的褪黑素/皮质醇比值显著高于精神分裂症患者。尽管这种关系的重要性仍有待阐明，但尤其可以提出褪黑素节律紊乱与精神分裂症之间存在功能关系。
