Hile David D, Kowaleski Michael P, Doherty Stephen A, Lewandrowski Kai-Uwe, Trantolo Debra J
Cambridge Scientific, Inc., 180 Fawcett Street St., Cambridge, MA 02138, USA.
Biomed Mater Eng. 2005;15(3):219-27.
A bioresorbable bone repair material made from the unsaturated polyester poly(propylene glycol-co-fumaric acid), PPF, was investigated for its potential to act as an adjunct to alleviate the disadvantages associated with wire fixation. The PPF bone repair material is an injectable system that can be delivered to the intramedullary site and crosslinked in the presence of a hydroxylapatite filler and effervescent agents. To test the feasibility of using a bioabsorbable material as an adjunct in fracture fixation, femoral osteotomies were created in two groups of 10 Sprague-Dawley rats. Osteotomies were fixed with a threaded Kirschner wire or stabilized with a Kirshner wire augmented with the PPF bone repair material. The quantity of new bone across the osteotomy site was assessed at 4 weeks postoperatively. Histologic analysis of the healing process revealed enhanced osteoconduction across the osteotomy with the PPF bone repair material. These findings were corroborated by histomorphometric analysis of new bone formation. These findings imply suitability of the PPF bone repair material to act as an adjunct to wire fixation, such as techniques used in hand surgery.
对一种由不饱和聚酯聚（丙二醇 - 共 - 富马酸）（PPF）制成的生物可吸收骨修复材料进行了研究，以评估其作为辅助材料减轻与钢丝固定相关缺点的潜力。PPF骨修复材料是一种可注射系统，可输送至骨髓腔内，并在羟基磷灰石填料和泡腾剂存在的情况下交联。为了测试使用生物可吸收材料作为骨折固定辅助材料的可行性，在两组各10只Sprague-Dawley大鼠中制造了股骨截骨术。截骨术用螺纹克氏针固定，或用添加了PPF骨修复材料的克氏针进行稳定。术后4周评估截骨部位的新骨量。愈合过程的组织学分析显示，使用PPF骨修复材料时，截骨部位的骨传导增强。新骨形成的组织形态计量学分析证实了这些发现。这些发现表明PPF骨修复材料适合作为钢丝固定的辅助材料，如手外科手术中使用的技术。
